Response: The role of carbonic anhydrase I and II enzymes in the pathogenesis of gestational diabetes mellitus and their relationship with oxidative stress

Response: The role of carbonic anhydrase I and II enzymes in the pathogenesis of gestational diabetes mellitus and their relationship with oxidative stressWe would like to express our sincere appreciation for the interest and thoughtful comments that Drs Amini and Mehri have shown in our recent publication, 1 which evaluated the relationship between carbonic anhydrase (CA) isoenzymes and oxidative stress in pregnancies affected by gestational diabetes mellitus (GDM).Their letter highlights the scientific value of further exploration of biochemical pathways that may contribute to the pathophysiology of GDM, a field in which research remains relatively limited despite its considerable clinical relevance.The authors correctly noted that CA-I and CA-II are primarily found in the cytosol of erythrocytes and various tissues rather than being actively secreted into the circulation.This important physiological detail supports the mechanistic interpretation that elevated circulating CA levels may indicate oxidative injury, increased cellular turnover, or compromised membrane stability, which are all commonly observed in GDM.2,3 Indeed, hyperglycemia-associated redox