Spinal cord injury induces acute microbiome shock and system‐wide transcriptomic reprogramming

iMeta 2026 Open access

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Authors: Chi Zhang, Yufei Du, Mingxin Wu, Chuang Li, Ruizhi Jiang, Enlin Qi, S Y Li, Xianfu Yi, Bo Chu, Shiqing Feng, Hengxing Zhou
DOI: 10.1002/imt2.70128
Cited by: 1
References: 20

Abstract

This study investigates the systemic consequences of spinal cord injury (SCI), with a particular focus on alterations in the gut microbiome and multi-organ transcriptomic responses. We identify a rapid and severe disruption of the gut microbiota-termed "microbiome shock"-that emerges within 12 h post-SCI and persists before gradually resolving by 5 days post-injury. To support further research in this field, we established an open-access resource, the Spinal Cord Injury Gut Microbiome and Multi-Organ Gene Expression Atlas (SCIGAMA).

Fields of Study & Subjects

Spinal Cord Injury Research Immune responses and vaccinations Immune cells in cancer

Publication details

Journal / source
iMeta
Publisher
Wiley
Volume
5
Issue
2
Pages
e70128–e70128
Publication date
1 April 2026
Language
EN