Single‐cell profiling of peripheral blood reveals acute‐phase immune dysregulation in human scrub typhus

iMeta 2026 Open access

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Authors: Yijia Guo, Yi Niu, Nihui Zhang, Han Xiao, Liyuan Zhang, Yongguo Du, Lifen Han, Xiuying Tian, Zhao Xu, Gaoyu Wang, Kwok-Yung Yuen, Jasper Fuk‐Woo Chan
+2 more Dahua Xu, Feifei Yin
DOI: 10.1002/imt2.70167
Cited by: 1
References: 16

Abstract

Integrated single-cell RNA sequencing, spectral flow cytometry, immune-receptor repertoire profiling, and plasma proteomics revealed coordinated peripheral immune remodeling during acute scrub typhus. Patients exhibited expansion of cytotoxic, clonally amplified CD8+ T cells with exhaustion-associated features, depletion and apoptosis of CD4+ T cells, B-cell contraction with enhanced plasmablast/plasma-cell differentiation, and inflammatory myeloid remodeling. CD14+CXCR6+ and CD14+GNLY+ myeloid-cell frequencies positively correlated with bacterial burden, defining prominent immune features of acute Orientia tsutsugamushi infection.

Fields of Study & Subjects

Vector-borne infectious diseases T-cell and B-cell Immunology Neuroinflammation and Neurodegeneration Mechanisms

Publication details

Journal / source
iMeta
Publisher
Wiley
Volume
5
Issue
4
Pages
e70167–e70167
Publication date
1 August 2026
Language
EN