Protocol‐Dependent Effects of Transcutaneous Blood Systemic Photobiomodulation on Inflammatory, Metabolic, and Hemostatic Markers

Blood systemic photobiomodulation (BSP) is an integrative approach using low-intensity lasers or LEDs. This is a therapeutic strategy to modulate inflammatory, metabolic, and hemostatic biomarkers, promoting potentially beneficial systemic effects. Fifty-six female volunteers participated in this study that investigated the effects of different transcutaneous photobiomodulation protocols applied over the radial artery, using red and infrared light under different dosimetry. Volunteers were allocated into experimental groups, and biomarkers were evaluated. Results show that the IR-V group exhibited a significant increase in HDL levels after treatment. Regarding insulin, a significant reduction was observed in the IR-LD group after treatment; ferritin levels were significantly reduced in the LED group. No significant differences were found for the other biomarkers analyzed. These findings reinforce the importance of personalizing photobiomodulation protocols and suggest that specific wavelength- and dose-dependent parameters may lead to distinct systemic biochemical responses.