Integrated LC ‐ OCT /Raman Microspectroscopy: A Novel Diagnostic Approach in Ophthalmology Demonstrated in a Case Study

Journal of Biophotonics 2026

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Authors: Meriem Ayadh, Dorado Cortez Christian, Jonas Ogien, Vanden-Bossche Arnaud, Florian Camy, Cinotti Elisa, Damien Grivet, Arnaud Dubois, Jean Perrot
DOI: 10.1002/jbio.70245
Cited by: 0
References: 14

Abstract

Integrated LC-OCT and Raman microspectroscopy enable the non-invasive identification of conjunctival hydroxyapatite calcifications, providing a dual morphological and molecular diagnostic approach. This bimodal technique successfully identifies microcrystals that are often undetectable by conventional histology due to their solubility and weak birefringence.

Fields of Study & Subjects

Spectroscopy Techniques in Biomedical and Chemical Research Optical Coherence Tomography Applications Ocular Surface and Contact Lens

Publication details

Journal / source
Journal of Biophotonics
Volume
19
Issue
3
Pages
e70245–e70245
Publication date
1 March 2026
Language
EN