Therapeutic Effect of Alpha‐Lipoic Acid Against Hepatotoxicity Induced by Multi‐Walled Carbon Nanotubes in Male Albino Rats

Journal of Biochemical and Molecular Toxicology 2026

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Authors: Esraa Emad El Dien, Yasmine H. Ahmed, Yasmine A. Mansour, Mona K. Galal, Maha M. Rashad, Shaymaa Hussein
DOI: 10.1002/jbt.70953
Cited by: 1
References: 86

Abstract

Multi-walled carbon nanotubes (MWCNTs) are advantageous for several medical and industrial applications. Alpha-lipoic acid (ALA) is a potent antioxidant. This study aimed to investigate the efficacy of ALA in mitigating hepatotoxicity caused by MWCNTs in male albino rats. Exposure to MWCNTs resulted in a significant increase in alanine transaminase (ALT) levels, along with elevated production of caspase-3. Simultaneously, they significantly diminished the mRNA expression levels of glutathione peroxidase. Furthermore, MWCNTs caused disorganization of hepatic plates, accompanied by inflammatory cell infiltration. Conversely, ALA treatment mitigated the detrimental effects induced by MWCNTs. Collectively, ALA substantially mitigates MWCNTs-induced hepatotoxicity through antioxidant, anti-inflammatory, and anti-apoptotic activities.

Fields of Study & Subjects

Biochemical Acid Research Studies Coenzyme Q10 studies and effects Natural Compounds in Disease Treatment

Publication details

Journal / source
Journal of Biochemical and Molecular Toxicology
Publisher
Wiley
Volume
40
Issue
6
Pages
e70953–e70953
Publication date
1 June 2026
Language
EN