Refractory Periorbital Necrobiotic Xanthogranuloma Treated With Plasma Cell‐Directed Therapy
Abstract
A 57-year-old female with a reported history of isolated neutropenia presented with 3 years of progressive bilateral vision loss and 4 months of a rapidly growing plaque on her FIGURE 1 Physical examination demonstrated necrobiotic xanthogranuloma skin lesions of the patient's left eyelid (A) and left upper thigh (C).MRI of the orbits demonstrated a left superomedial preseptal mass (B) that resolved after treatment with plasma cell-directed therapy (D).left eyelid (Figure 1A ).MRI of the orbits revealed a 1.4 cm left superomedial preseptal mass with retroseptal extension (Figure 1B ).On pathological analysis after left anterior orbitotomy, biopsy
Fields of Study & Subjects
Histiocytic Disorders and Treatments
Genetic and rare skin diseases.
Skin Diseases and Diabetes
Publication details
- Journal / source
- eJHaem
- Publisher
- Wiley
- Volume
- 7
- Issue
- 1
- Pages
- e70223–e70223
- Publication date
- 19 January 2026
- Language
- EN