Indole‐Based π‐Extended Monophosphine Ligands for Enhanced Palladium‐Catalyzed Sonogashira Coupling

Journal of Heterocyclic Chemistry 2026 Open access

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Authors: Yu Kiu Lau, Chun Pong Hui, Cheuk Long Li, H. M. CHANG, Man Ho Tse, Ho Kwan Lou, Iat In Chan, Raymond Wai‐Yin Sun, Pui Ying Choy, Fuk Yee Kwong
DOI: 10.1002/jhet.70151
Cited by: 3
References: 70

Abstract

ABSTRACT A general palladium‐catalyzed Sonogashira cross‐coupling reaction of aryl and heteroaryl chlorides with aliphatic, aryl and heteroaryl alkynes is described. The Pd(dba)₂/ PCy 2 ‐Napdole‐phos catalyst system efficiently promotes the reaction, exhibiting broad substrate scope and excellent functional group tolerance. Notably, the catalyst loading can be down to 0.2 mol% Pd. The PCy 2 ‐Napdole‐phos , featuring an extended π‐system provides substantial steric bulk to facilitate the construction of C(sp 2 )—C(sp) bonds.

Fields of Study & Subjects

Catalytic Cross-Coupling Reactions Catalytic C–H Functionalization Methods Catalytic Alkyne Reactions

Publication details

Journal / source
Journal of Heterocyclic Chemistry
Publisher
Wiley
Volume
63
Issue
4
Pages
727–737
Publication date
4 February 2026
Language
EN