Visible Light‐Driven Multicomponent Synthesis of N ‐Arylquinolines Under Green Synthetic Approach

Journal of Heterocyclic Chemistry 2026 Open access

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Authors: Vishwa K. Patel, Divyani P. Patel, Satish Kumar Singh
DOI: 10.1002/jhet.70159
Cited by: 1
References: 51

Abstract

ABSTRACT This easy, efficient protocol employs a green, metal‐free multicomponent strategy for the rapid synthesis of N ‐arylquinolines under visible‐light irradiation. The one‐pot reaction between aromatic aldehydes, 5,5‐dimethyl‐3‐(phenylamino)cyclohex‐2‐en‐1‐one (enaminone), and malononitrile or ethyl cyanoacetate proceeds smoothly in ethanol under blue LED irradiation (12 W) at room temperature, affording excellent yields within 2–3 h. The use of visible light as a clean energy source eliminates the need for thermal heating or metal catalysts, highlighting an environmentally benign and energy‐efficient route to biologically relevant N ‐arylquinolines.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Catalytic C–H Functionalization Methods Radical Photochemical Reactions

Publication details

Journal / source
Journal of Heterocyclic Chemistry
Publisher
Wiley
Volume
63
Issue
4
Pages
607–613
Publication date
11 January 2026
Language
EN