Lewis Acid–Catalyzed Annulation of 2(Trifluoroacetyl)pyrroles Leading to CF 3 ‐Substituted Polycyclic Quinazolinones
Abstract
ABSTRACT A novel and efficient cascade annulation of 2‐aminobenzamides with N ‐aryl 2‐(trifluoroacetyl)pyrroles has been developed, providing a straightforward route to CF 3 ‐substituted quinazolinones. The reaction proceeds smoothly under mild conditions via a dehydrative annulation pathway, enabling the formation of a C–N bond in a single operation. This transformation effectively incorporates the trifluoromethyl group into the quinazolinone framework, affording structurally diverse CF 3 ‐substituted quinazolinones in good to excellent yields. This methodology provides a practical approach for the synthesis of fluorine‐containing heterocycles of potential pharmaceutical interest.
Fields of Study & Subjects
Quinazolinone synthesis and applications
Catalytic C–H Functionalization Methods
Multicomponent Synthesis of Heterocycles
Publication details
- Journal / source
- Journal of Heterocyclic Chemistry
- Publisher
- Wiley
- Volume
- 63
- Issue
- 4
- Pages
- 717–726
- Publication date
- 3 February 2026
- Language
- EN