Transition‐Metal‐Free C‐1 Arylation of Isoquinolines With Arylhydrazine Salts

Journal of Heterocyclic Chemistry 2026

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Authors: Xing Wang, Caifu Deng, Yongdong Yang, Aibo Liu, Shenggang Yang, Rong Tan, Ling Li, Lei Tang, Cong Wang
DOI: 10.1002/jhet.70168
Cited by: 0
References: 28

Abstract

ABSTRACT A transition‐metal‐free synthesis of 1‐arylisoquinolines has been achieved using arylhydrazine salts as arylating reagents in the presence of K 2 CO 3 and K 2 S 2 O 8 . This protocol is metal‐free, requires no specific ligands, and is characterized by operational simplicity, reliability, mild conditions, and environmental benignity. It is thus applicable for constructing bioactive molecules containing the 1‐arylisoquinoline scaffold.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Sulfur-Based Synthesis Techniques Radical Photochemical Reactions

Publication details

Journal / source
Journal of Heterocyclic Chemistry
Volume
63
Issue
4
Pages
710–716
Publication date
2 February 2026
Language
EN