Efficient Synthesis of Spirocyclic Pyrrolidinones via [3+2] Cyclization of α ‐Bromohydroxamates

Journal of Heterocyclic Chemistry 2026

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Authors: Min Xiang, Si-Si Luo, Jiang‐Li Ran, Guang‐Wei Wang, Yun‐Qing Jia, Li‐Wen Shen
DOI: 10.1002/jhet.70204
Cited by: 1
References: 36

Abstract

ABSTRACT A mild and efficient [3+2] cyclization of α ‐bromohydroxamates with 4‐benzylidene‐pyrazolones is reported herein for the rapid assembly of spiro‐pyrrolidinones. Broad substrate scope, excellent functional group tolerance, and successful gram‐scale demonstration highlight the synthetic utility of this protocol. This method offers a straightforward and scalable approach to densely functionalized spirocyclic architectures.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Synthesis and Reactivity of Heterocycles Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Journal of Heterocyclic Chemistry
Publisher
Wiley
Volume
63
Issue
7
Pages
1159–1166
Publication date
28 April 2026
Language
EN