HIV low‐level viraemia: considerations for prevention and treatment in an era of highly effective and durable antiretroviral therapy regimens

Journal of the International AIDS Society 2026 Open access

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Authors: Lara Vojnov, Linda-Gail Bekker, Myron S. Cohen, Andreas Jahn, Diane Havlir, Debrah I. Boeras, Nathan Ford, Nagalingesawaran Kumarasamy, Laura N. Broyles
DOI: 10.1002/jia2.70085
Cited by: 3
References: 49

Abstract

INTRODUCTION: Despite increasingly widespread acceptance of the (undetectable = untransmittable) U = U concept, uncertainty remains about the implications of suppressed viral loads (detected but ≤1000 copies/ml, also often referred to as low-level viraemia) for both sexual HIV transmission and individual patient outcomes. DISCUSSION: There has been no documented evidence of a transmission event when the index partner had a viral load

Fields of Study & Subjects

HIV/AIDS Research and Interventions HIV/AIDS drug development and treatment HIV Research and Treatment

Publication details

Journal / source
Journal of the International AIDS Society
Publisher
Wiley
Volume
29
Issue
2
Pages
e70085–e70085
Publication date
1 February 2026
Language
EN