Fully Automated Production of Multiple 11 C‐Labeled PET Tracers Using a Self‐Cleaning TracerMaker Radiosynthesizer

ABSTRACT The rapid translation of carbon‐11 PET radiotracers into clinical and preclinical research requires automated synthesis modules capable of fast, reliable, and reproducible production. Here, we report the development and application of a fully automated TracerMaker radiosynthesizer for routine production of multiple 11 C‐labeled PET tracers at the PET Research Core, Stony Brook University. The system integrates automated Sep‐Pak preconditioning, in‐line sterile filter integrity testing, and a fully automated postproduction cleaning protocol that significantly reduces operator workload and radiation exposure. Using this module, three radiotracers with high clinical research interest, ( E )‐3‐(6‐methyl‐pyridin‐2‐ylethynyl)‐cyclohex‐2‐enone‐O‐ 11 C‐methyl‐oxime (( E )‐[ 11 C]ABP688), 5‐(4‐(Methoxy‐ 11 C)phenyl)‐1‐(4‐methoxyphenyl)‐3‐(2,2,2‐trifluoroethoxy)‐1H‐1,2,4‐triazole ([ 11 C]PS13), and 11 C‐labeled Pittsburgh Compound B ([ 11 C]PiB) were successfully produced without hardware modification. The automated cleaning protocol enables rapid turnaround between runs and supports high‐throughput sequential production. These results demonstrate that the TracerMaker module provides a robust, flexible, and cost‐effective platform for the routine clinical production of carbon‐11 radiopharmaceuticals.