Percutaneous Left Atrial Appendage Occlusion for Atrial Fibrillation in Cardiac Amyloidosis

Journal of Arrhythmia 2026 Open access

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Authors: Abdul Hakim Almakadma, Ramzi Ibrahim, Hoang Nhat Pham, Eiad Habib, Ahmed Mahmoud, Kamal Awad, Mayurkumar D. Bhakta, Eric H. Yang, Hicham El Masry, Chadi Ayoub, Reza Arsanjani
DOI: 10.1002/joa3.70274
Cited by: 0
References: 5

Abstract

Background: Cardiac amyloidosis (CA) is frequently complicated by atrial fibrillation (AF), yet outcomes after left atrial appendage occlusion (LAAO) in this population remain poorly defined. Methods: We conducted a retrospective TriNetX study of adults with AF undergoing LAAO, comparing patients with and without CA after 1:1 propensity matching. Outcomes were assessed using Kaplan-Meier analyses and Cox regression. Results: Among 532 matched pairs, mortality and major adverse cardiovascular events were similar between groups, whereas major bleeding was higher in CA (HR 1.90). Conclusions: LAAO yields comparable ischemic outcomes in CA, though bleeding risk is increased.

Fields of Study & Subjects

Atrial Fibrillation Management and Outcomes Amyloidosis: Diagnosis Treatment Outcomes Cardiac Arrhythmias and Treatments

Publication details

Journal / source
Journal of Arrhythmia
Volume
42
Issue
1
Pages
e70274–e70274
Publication date
26 January 2026
Language
EN