Risk of Crohn's disease in children presenting with perianal abscess and fistula increases with age: A multicenter study

Journal of Pediatric Gastroenterology and Nutrition 2026 Open access

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Authors: Mariëlle Roskam, Thomas H. Dierikx, Sanne Hulsmann, Jesse Lemmen, Vanessa J. Leijdekkers, Joanna Luttikhold, Frank P. Garssen, Dunker Ms, Jarmila van der Bilt, Justin de Jong, Ernst van Heurn, N De Boer
+2 more Roel Bakx, Tim de Meij
DOI: 10.1002/jpn3.70373
Cited by: 1
References: 23

Abstract

OBJECTIVES: Perianal abscesses (PA) and fistulas-in-ano (FIA) are frequently diagnosed in children and may be presenting symptoms of Crohn's disease (CD). The association between age at presentation of PA/FIA and the risk of subsequent CD development is largely unknown. Aim of this study was to investigate the association between PA/FIA and risk for CD development, stratified by age. METHODS: In this retrospective multicenter study children between 2 and 18 years presenting with PA/FIA, were included. Patient characteristics, biochemical data, and data on CD development were collected. The risk of developing IBD was stratified by age in three subgroups (

Fields of Study & Subjects

Anorectal Disease Treatments and Outcomes Diverticular Disease and Complications Appendicitis Diagnosis and Management

Publication details

Journal / source
Journal of Pediatric Gastroenterology and Nutrition
Publisher
Wiley
Volume
82
Issue
5
Pages
1226–1232
Publication date
25 February 2026
Language
EN