Long Term Metabolic Outcomes Following Pancreatectomy and Autologous Islet Transplantation: Systematic Review and Meta‐Analysis

Journal of Surgical Oncology 2026 Open access

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Authors: D L Hughes, Caterina Di Bella, Benedetta Quaratino, Pietro Rigo, Giulia Cirillo, Gioia Sgrinzato, Umberto Cillo, Lucrezia Furian, Giovanni Marchegiani
DOI: 10.1002/jso.70193
Cited by: 1
References: 37

Abstract

This systematic review and meta-analysis assessed long-term outcomes following total pancreatectomy with islet autotransplantation (TPIAT). Seventeen studies including 1332 patients were analyzed. The pooled insulin independence rate was 34%, with higher rates for non-chronic pancreatitis indications (68%) versus chronic pancreatitis (33%). TPIAT is effective in preserving endocrine function. Further studies are needed to validate outcomes across extended indications and to standardize reporting, incorporating metabolic markers and patient-reported quality-of-life endpoints over long-term follow-up.

Fields of Study & Subjects

Pancreatic function and diabetes Renal Transplantation Outcomes and Treatments Organ Transplantation Techniques and Outcomes

Publication details

Journal / source
Journal of Surgical Oncology
Publisher
Wiley
Volume
133
Issue
4
Pages
475–485
Publication date
8 January 2026
Language
EN