A Rare SMARCA4 ‐Deficient Subglottic Adenoid Cystic Carcinoma With Early Pulmonary Metastasis
Abstract
This report describes a rare primary subglottic adenoid cystic carcinoma harboring a SMARCA4 loss-of-function mutation, a molecular driver not previously reported in this anatomical site. Despite presenting with locally advanced pT4a disease and early pulmonary metastasis, the patient achieved 5-year local control following total laryngectomy and adjuvant radiotherapy. The findings suggest that molecular profiling can identify non-MYB-driven subtypes and guide individualized management for atypical laryngeal malignancies.
Fields of Study & Subjects
Head and Neck Cancer Studies
Salivary Gland Tumors Diagnosis and Treatment
Chromatin Remodeling and Cancer
Publication details
- Journal / source
- The Laryngoscope
- Volume
- 136
- Issue
- 8
- Pages
- 3473–3476
- Publication date
- 13 March 2026
- Language
- EN