MEK Inhibitor Associated Airway Injury in an Infant With Noonan Syndrome: A Case Report

The Laryngoscope 2026 Open access

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Authors: Veronica Drozdowski‐Nuccio, Rachel D. Yoon, Steven Tomasi, Dana M. Thompson, Inbal Hazkani
DOI: 10.1002/lary.70749
Cited by: 1
References: 4

Abstract

An infant with Noonan syndrome treated with trametinib developed extensive mucosal sloughing of the upper and lower airway, followed by severe supraglottic scarring. Clinicians should consider airway toxicity as a potential adverse effect of MEK inhibitor therapy.

Fields of Study & Subjects

Protein Tyrosine Phosphatases Neurofibromatosis and Schwannoma Cases Curcumin's Biomedical Applications

Publication details

Journal / source
The Laryngoscope
Publisher
Wiley
Publication date
26 July 2026
Language
EN