Breaking the Resolution Barrier in Incoherent Structured Illumination Microscopy via High‐Modulation Coefficient Mapping and Principal Component Analysis (PCA‐iSIM) (Laser Photonics Rev. 20(3)/2026)

Laser & Photonics Review 2026 Open access

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Authors: Maoxian Zhang, Xinyu Han, Jiaming Qian, Hongjun Wu, Tianchi Kang, Dongqin Lu, Jing Feng, Weihao Cheng, Yuzhen Zhang, Qian Chen, Chao Zuo
DOI: 10.1002/lpor.70881
Cited by: 0

Abstract

Breaking the Incoherent SIM Barrier A compact incoherent DMD-SIM platform empowered by high-modulation coefficient mapping and principal component analysis (PCA) to overcome weak fringe visibility enables robust illumination parameter recovery and delivers real-time live-cell super-resolution imaging with >1.9× resolution gain (≈100°nm) at 30°Hz. More information can be found in Research Article e01957 by Jiaming Qian, Yuzhen Zhang, Qian Chen, Chao Zuo and co-workers.

Fields of Study & Subjects

Advanced Fluorescence Microscopy Techniques Digital Holography and Microscopy Advanced Optical Imaging Technologies

Publication details

Journal / source
Laser & Photonics Review
Volume
20
Issue
3
Publication date
1 February 2026
Language
EN