Bilateral Globus Pallidus Deep Brain Stimulation Improves Motor Function in ADCY5 ‐Related Disorder

BACKGROUND: ADCY5-related disorder is characterized by disabling hyperkinetic movement disorders. The therapeutic impact of deep brain stimulation (DBS) has not been systematically evaluated. OBJECTIVES/METHODS: This work involved a multicenter cohort study of 8 children with genetically confirmed ADCY5-related movement disorders treated with bilateral globus pallidus internus (GPi) DBS. RESULTS: The mean age at initiation of DBS was 12.9 years (range: 3.5-18). All patients demonstrated improvement in baseline hyperkinesia and paroxysmal exacerbations. Mean Burke-Fahn-Marsden Dystonia Rating Scale motor scores decreased from 50.7 to 22.7 (p = 0.019, d = 1.19). Functional gains included new or recovered motor milestones, improved speech and swallowing, and resolution of sleep-related dyskinesias. There were no perioperative complications. CONCLUSIONS: GPi-DBS is a safe and effective therapy for ADCY5-related movement disorders, offering sustained motor and functional improvement. These findings support earlier consideration of DBS to reduce disease burden, preserve function, and improve long-term outcomes. © 2026 International Parkinson and Movement Disorder Society.