The Bioavailability of Xanthohumol in Humans and the Influence of Formulation and Dose: Randomized Controlled Trial Data

Molecular Nutrition & Food Research 2026 Open access

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Authors: Sara Brehmer‐Henkel, Christina Diekmann, Marit Eickeler, Ronja Maris, Christina Kopp, Martin Coenen, Robert Németh, Birgit Stoffel‐Wagner, Nadine Sus, Jan Frank, Sarah Egert
DOI: 10.1002/mnfr.70413
Cited by: 2
References: 40

Abstract

ABSTRACT Xanthohumol is a prenylated chalcone, which is mainly found in hops. Experimental studies show a variety of cardioprotective effects for xanthohumol, but so far there are only a few controlled studies on the bioavailability and efficacy of xanthohumol in humans. In a randomized crossover bioavailability trial, the plasma kinetics of 86 mg and 172 mg each of micellar or native xanthohumol were investigated. Blood samples were obtained at fasting ( t 0 ), regularly until 9 h and 24 h after oral xanthohumol bolus administration and the plasma concentrations of xanthohumol, xanthohumol glucuronide, and xanthohumol sulfate were analyzed. Micellation increased the area under the plasma concentration–time curve (AUC) ( p < 0.001) and maximum plasma concentration ( p

Fields of Study & Subjects

Hops Chemistry and Applications Natural Compound Pharmacology Studies Saffron Plant Research Studies

Publication details

Journal / source
Molecular Nutrition & Food Research
Publisher
Wiley
Volume
70
Issue
4
Pages
e70413–e70413
Publication date
1 February 2026
Language
EN