Hybrid Nanocrystalline Theranostic Agents Designed for Magnetic Resonance Imaging, Photothermal, and Photodynamic Therapies Against Cancer

Nano Select 2026 Open access

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Authors: Yiqian Wang, Pierre Begon de Larouziere, Joana Pereira, Augustin Debard, Léa Sanvee, Jérôme Gâteau, Aude Michel Tourgis, Christine Ménager, Cyrille Richard, Charlotte Izabelle, Xiangzhen Xu, Pierre Mesdom
+4 more Nathalie Mignet, Gilles Gasser, Yohann Corvis, Bich‐Thuy Doan
DOI: 10.1002/nano.70123
Cited by: 1
References: 56

Abstract

ABSTRACT Photodynamic therapy (PDT) is a promising, effective, and non‐invasive treatment for superficial cancers, utilizing reactive oxygen species (ROS) generated by induced light‐irradiated photosensitizers (PS) to provoke cancer cell death. Photothermal therapy (PTT) on the other hand, relies on heat generation by light‐irradiated PS for effective thermal cancer treatment. Both treatments have limitations when applied individually; however, a synergistic approach combining both PDT and PTT could overcome these shortcomings. Protoporphyrin (PpIX) is an effective and widely used PS for PDT but in its molecular form, its application is hindered by significant biopharmaceutical drawbacks, such as high hydrophobicity.

Fields of Study & Subjects

Nanoplatforms for cancer theranostics Photodynamic Therapy Research Studies Advanced Nanomaterials in Catalysis

Publication details

Journal / source
Nano Select
Publisher
Wiley
Volume
7
Issue
5
Publication date
1 May 2026
Language
EN