Front Cover: Ruthenium‐Catalyzed CH Alkenylation of Trypanocidal Naphthoquinones: A Mechanistic Benchmarking Study (ChemistryOpen 2/2026)

ChemistryOpen 2026 Open access

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Authors: Esther R. S. Paz, Cauê P. Souza, Joyce C. Oliveira, Renata G. Almeida, Chonny Herrera‐Acevedo, Sulaiman Lakoh, Guilherme A. M. Jardim, Eufrânio N. da Silva Júnior, Felipe Fantuzzi
DOI: 10.1002/open.70155
Cited by: 0

Abstract

The Front Cover image highlights a computational study of the Ru(II)-catalyzed C–H alkenylation of menadione with ethenesulfonyl fluoride, enabling SuFEx functionalization of quinones. Density functional benchmarking against DLPNO-CCSD(T) establishes a robust mechanistic picture and supports the rational design of naphthoquinone derivatives targeting Trypanosoma cruzi. More details are available in the Research Article by Felipe Fantuzzi and co-workers (DOI: 10.1002/open.202500465).

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Organometallic Complex Synthesis and Catalysis Catalytic Cross-Coupling Reactions

Publication details

Journal / source
ChemistryOpen
Volume
15
Issue
2
Publication date
1 February 2026
Language
EN