A Stepwise Approach to 1,4,10,13‐Tetraaza‐18‐Crown‐6 Ether
Abstract
A two-step approach to the synthesis of tetraaza-18-crown-6 ether was evaluated to address the limitations of the currently used one-step macrocyclization, such as low yield due to substantial side product formation. In this route, the reaction conditions were optimized, reducing cyclization to the undesired nine-membered ring by a factor of eight. This resulted in a 50% yield for the two-step macrocyclization, or 28% when column chromatography was avoided, both significantly higher than the 16% yield obtained when reproducing the one-step method.
Fields of Study & Subjects
Chemical Synthesis and Analysis
Molecular Sensors and Ion Detection
Click Chemistry and Applications
Publication details
- Journal / source
- ChemistryOpen
- Publisher
- Wiley
- Volume
- 15
- Issue
- 5
- Pages
- e70201–e70201
- Publication date
- 1 May 2026
- Language
- EN