Therapeutic Potential and Mechanisms of Curcumin in Cardiovascular Diseases: A Comprehensive Review
Abstract
BACKGROUND: Curcumin is recognized for its therapeutic potential in cardiovascular diseases (CVDs), with effects on cardiomyocytes, vascular function, and hypertrophy. OBJECTIVE: This review aims to evaluate curcumin's therapeutic effects, mechanisms of action, and safety in CVD management. METHODS: A comprehensive review of existing literature was conducted, focusing on curcumin's impact on ischemia, hypoxia, myocardial hypertrophy, fibrosis, and endothelial function. RESULTS: Curcumin protects cardiomyocytes, enhances vascular function, and exhibits inconsistent effects on cholesterol accumulation in macrophages. CONCLUSION: While curcumin shows promise as a complementary agent in CVD management, further research, particularly large-scale clinical trials, is essential to validate its efficacy and safety.
Fields of Study & Subjects
Curcumin's Biomedical Applications
Flavonoids in Medical Research
Cardiovascular Disease and Adiposity
Publication details
- Journal / source
- Phytochemical Analysis
- Publisher
- Wiley
- Volume
- 37
- Issue
- 3
- Pages
- 348–361
- Publication date
- 30 January 2026
- Language
- EN