Toward a Modern Telehealth Follow‐Up Routine for Radical Prostatectomy: Introducing a Novel E‐Health Application for Outcome and Complication Assessment

BACKGROUND: To implement "MeinLUKS," an automated e-health follow-up system within the EPIC MyChart portal after radical prostatectomy (RP), and to examine factors influencing portal adoption, as well as functional and oncological outcome differences between users and non-users. METHODS: We retrospectively analyzed men undergoing RP at a tertiary center (January/2022-October/2023). Patients were classified as "users" if they submitted follow-up data via MeinLUKS or "non-users" if monitored through referring physicians. Sociodemographic, clinical, functional, and oncological outcomes were retrieved from institutional registries and included standardized patient-reported outcome measures. Both groups were invited to structured telephone interviews addressing barriers and facilitators of adoption. RESULTS: Of 274 patients, 128 (47%) used MeinLUKS and 146 (53%) relied on traditional follow-up. Users were younger, more educated, and often urban residents, while oncological characteristics were comparable. Median time to no pad use was not different (11 vs. 28 days, p = 0.3) with similar long-term continence (79% vs. 73% pad-free, p = 0.3). Patient reported sexual function recovery was better among users (56% vs. 36%, p = 0.01). MeinLUKS automatically flagged two biochemical recurrences and unreported complications not identified in routine care. Among 91 interviewees, users emphasized organizational benefits and digital competence, while non-users cited poor onboarding, limited physician advocacy, and interface complexity. Limitations include single-center, retrospective design and non-randomized comparisons. CONCLUSIONS: Automated e-health follow-up improved data completeness, reduced workforce demands, and detected clinically relevant events missed in routine care. Optimizing onboarding, clinician engagement, and usability may increase adoption and enhance quality and efficiency in prostate cancer survivorship care.