Physiologically Based Pharmacokinetic Modeling in Patients With Hepatic Impairment: Are Changes in Bosutinib Exposure Profiles Driven by Altered Absorption or Distribution?
Abstract
Bosutinib is an orally available Src/Abl tyrosine kinase inhibitor and has been approved for the treatment of patients with Ph + chronic myelogenous leukemia. Bosutinib is a substrate of P-glycoprotein (P-gp) in vitro and is predominantly metabolized by CYP3A4 in humans with minimal urinary excretion. We present our perspective on using physiologically based pharmacokinetic modeling to understand the atypical changes in oral exposure of bosutinib, a CYP3A and P-gp substrate, in hepatic impairment patients.
Fields of Study & Subjects
Pharmacogenetics and Drug Metabolism
Drug Transport and Resistance Mechanisms
Pharmaceutical studies and practices
Publication details
- Journal / source
- CPT Pharmacometrics & Systems Pharmacology
- Volume
- 15
- Issue
- 1
- Pages
- e70179–e70179
- Publication date
- 1 January 2026
- Language
- EN