Beta‐3 Adrenoreceptor Agonist Mirabegron Improves Right Ventricular Function in a Rat Monocrotaline‐Induced Pulmonary Hypertension Model

Pulmonary Circulation 2026 Open access

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Authors: Pedro Mendes‐Ferreira, Birger Tielemans, Allard Wagenaar, C. Bouzin, Rui Adão, Péter Pokreisz, Delphine De Mulder, Adelino Ferreira Leite-Moreira, Carmen Brás‐Silva, Jean‐Luc Balligand, C. Dessy, M. Delcroix
+2 more Rozenn Quarck, Catharina Belge
DOI: 10.1002/pul2.70232
Cited by: 1
References: 12

Abstract

Considering the beta-3 adrenoceptor agonist, mirabegron, may display vasodilator and cardioprotective properties, we investigated the therapeutic potential of mirabegron in monocrotaline-induced pulmonary hypertension in rats. High-dose mirabegron improved right ventricular function, and endothelium-dependent relaxation in isolated rat pulmonary arteries, suggesting that mirabegron may be beneficial in pulmonary arterial hypertension.

Fields of Study & Subjects

Pulmonary Hypertension Research and Treatments Circadian rhythm and melatonin Eicosanoids and Hypertension Pharmacology

Publication details

Journal / source
Pulmonary Circulation
Publisher
Wiley
Volume
16
Issue
1
Pages
e70232–e70232
Publication date
1 January 2026
Language
EN