A Rare Case of Necrotising Sarcoid Granulomatosis Presenting as Bilateral Pulmonary Masses Mimicking Malignancy

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Authors: Jacqueline Chung, Rory O’Donnell, Ayan Sabih
Cited by: 0
References: 3

Abstract

Necrotising sarcoid granulomatosis (NSG) is a rare granulomatous lung disease characterised by non-caseating granulomas, necrosis, and vasculitis. We describe a 50-year-old man who presented with constitutional symptoms and bilateral pulmonary masses initially suggestive of metastatic malignancy. Extensive infectious, malignant, and autoimmune workup was negative. Histopathology from lung biopsies and a video-assisted thoracoscopic surgery (VATS) resection revealed granulomatous inflammation with necrosis and no evidence of malignancy or infection. A trial of corticosteroids resulted in clinical, biochemical, and radiological improvement. This case highlights the diagnostic challenges of NSG and the importance of multidisciplinary evaluation to avoid misdiagnosis.

Fields of Study & Subjects

Sarcoidosis and Beryllium Toxicity Research Ocular Diseases and Behçet’s Syndrome Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis

Publication details

Journal / source
Respirology Case Reports
Volume
14
Issue
1
Pages
e70449–e70449
Publication date
1 January 2026
Language
EN