Unlocking the potential of stimuli‐responsive liquid crystal polymer bio‐interfaces for adaptive cell modulation

Abstract This Perspective discusses the potential of stimuli‐responsive liquid crystal polymer (LCP) bio‐interfaces in modulating cell behavior as next generation dynamic artificial scaffolds. Unlike current artificial biomaterials that have static properties, LCPs offer fast, reversible, and spatially programmable deformation that reflects the dynamic properties of the natural materials and systems. In this Perspective, we first outline static materials and key interface properties known to influence cellular processes, then provide an overview of LCPs operating under physiological conditions, crosslinking strategies, and alignment mechanisms relevant for designing responsive systems. Subsequently, we reorganize existing findings on LCP bio‐interfaces into two conceptual categories: (1) static LCPs that demonstrate baseline biocompatibility and cellular alignment effects, and (2) dynamic LCPs that enable externally triggered dynamics for on‐demand mechanomodulation. The categorization highlights that, despite their intrinsic stimuli‐responsiveness, LCP‐based dynamic bio‐polymer interfaces remain scarcely explored in cellular studies. Finally, we discuss current material limitations, operational challenges under physiological conditions, and technological barriers such as stiffness mismatch, biocompatibility, and stimulus compatibility, and propose future research directions for unlocking adaptive, multi‐stimuli‐responsive, and integrated‐readout LCP platforms for cell modulation.