A Functional Approach to Testing Overall Effect of Interaction Between DNA Methylation and SNPs

Statistics in Medicine 2026 Open access

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Authors: Yvelin Gansou, Karim Oualkacha, Marzia Angela Cremona, Lajmi Lakhal‐Chaieb
DOI: 10.1002/sim.70364
Cited by: 0
References: 32

Abstract

We introduce a test for the overall effect of interaction between DNA methylation and a set of single nucleotide polymorphisms on a quantitative phenotype. The developed inference procedure is based on a functional approach that extend existing regression models in functional data analysis. Through extensive simulations, we show that the proposed test effectively controls type I error rates and highlights increased empirical power over existing methods, particularly when multiple interactions are present. The use of the proposed test is illustrated with an application to data from obesity patients and controls.

Fields of Study & Subjects

Genetic Associations and Epidemiology Statistical Methods and Inference Epigenetics and DNA Methylation

Publication details

Journal / source
Statistics in Medicine
Volume
45
Issue
1-2
Pages
e70364–e70364
Publication date
1 January 2026
Language
EN