High‐Performance Flexible Nonenzymatic Uric Acid Biosensor Based on Cu‐Doped Polyaniline–Graphene Nanocomposite

ABSTRACT In recent years, the use of flexible wearable devices to monitor human health signals has great potential for application in personalized health monitoring and preventive medicine. The most challenging task is to construct wearable sensing electrode that can detect relevant biochemical indicators in body fluids. In this study, Cu‐doped polyaniline–graphene nanocomposite (Cu@PANI‐GNP) was first prepared through the metal ion doping to obtain excellent conductivity and electrocatalytic activity even in physiologically neutral environment. Then, a novel wearable sensing electrode was constructed with nonwoven fabric (NWF) as a flexible support. One side was coated with a conductive graphene coating (GC), and the other side was coated with the Cu@PANI‐GNP electrode material. This resulting Cu@PANI‐GNP/GC‐NWF electrode can detect the uric acid concentration within the range of 7.15×10 −5 –1.43×10 −3 M, with 0.8 µA mM −1 sensitivity. This detection range is well‐suited for clinical applications. This electrochemical sensor enables the separation of interfering signals through potential‐controlled techniques, demonstrating significant potential for application in both clinical diagnostics and home healthcare.