Biotin‐Modified Boron‐Doped Carbon Dots as a Targeted Platform for Boron Neutron Capture Therapy

ABSTRACT Boron neutron capture therapy (BNCT) is a promising cancer treatment strategy, yet its clinical application is hindered by the lack of efficient boron delivery agents. Herein, we developed biotin‐derived boron‐doped carbon dots (Bio‐CDs) as a novel multifunctional nanotherapeutic platform for targeted BNCT. Bio‐CDs were synthesized using biotin as the carbon source and boric acid ( 10 B) as the boron donor. The resulting Bio‐CDs demonstrated exceptionally high boron loading, excellent water dispersibility, and strong biotin receptor‐mediated tumor‐targeting capability. In vitro and in vivo studies confirmed superior BNCT efficacy with negligible systemic toxicity. Furthermore, the Bio‐CDs exhibited favorable pharmacokinetic properties, biocompatibility, and scalable synthesis from readily available materials. This multifunctional platform integrates high boron content, active targeting, and favorable biosafety, offering a scalable and clinically translatable solution for precision BNCT. The development of Bio‐CDs provides a new strategy for overcoming limitations of existing boron agents and advancing the clinical utility of BNCT in cancer therapy.