TIBAL‐Assisted Copper‐Catalyzed Ketone‐Amine‐Alkyne (KA 2 ) Reaction for Preparation of α‐Tertiary Propargylamines in Mild Conditions
Abstract
ABSTRACT The addition of 0.6 equivalent of TIBAL promotes copper‐catalyzed KA 2 reaction in dichloromethane at room temperature. Alkyl‐ and aryl‐substituted terminal alkynes, α,ω‐diynes, a number of secondary amines (piperidine, pyrrolidine), and a number of ketones (cyclohexanone, cyclopentanone, acetone, 2‐octanone) were involved in the KA 2 reaction to prepare α‐tertiary propargylamines in good yield. The reaction with α,ω‐diynes leads to selective formation of the products of mono‐aminomethylation.
Fields of Study & Subjects
Catalytic Alkyne Reactions
Click Chemistry and Applications
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- ChemistrySelect
- Volume
- 11
- Issue
- 8
- Publication date
- 1 February 2026
- Language
- EN