Harnessing Copper: Efficient O‐Arylation of Haloarenes via N 4 ‐Tetradentate Dicarboxyamidate Ligand
Abstract
ABSTRACT We report a highly effective Cu 2 O‐catalyzed O‐arylation strategy for the synthesis of diaryl ethers, enabled by a structurally robust N 4 ‐tetradentate dicarboxyamidate ligand. The reaction proceeds efficiently in DMF at 120°C using cesium carbonate as the base, affording high yields under operationally simple and scalable conditions. The catalytic system demonstrates broad substrate tolerance, encompassing complex chloroarenes having electron withdrawing groups alongside a wide variety of phenols.
Fields of Study & Subjects
Catalytic Cross-Coupling Reactions
Catalytic C–H Functionalization Methods
Sulfur-Based Synthesis Techniques
Publication details
- Journal / source
- ChemistrySelect
- Volume
- 11
- Issue
- 11
- Publication date
- 1 March 2026
- Language
- EN