Determination of Water Content in Organic Compounds Using Proton Nuclear Magnetic Resonance ( 1 H‐NMR) Spectroscopy

ABSTRACT A simple method for determining water content in organic compounds has been demonstrated using Proton Nuclear Magnetic Resonance ( 1 H‐NMR) Spectroscopy. The method has been successfully applied to measure water content in a diverse range of substances, including active pharmaceutical ingredients (APIs), sugar molecules, commercial building blocks, and various solvents. Comparative analyses with Karl Fischer titration (KFT) demonstrate high consistency with this NMR approach, confirming its reliability as an adaptable alternative for water content determination in organic compounds. The current technique offers rapid execution, requires very small sample quantities, accommodates diverse substrates, and enables quantification without precise analyte measurements.