Safe and Controllable Azidochlorination of Olefins With in Situ Generated Chlorine Azide
Abstract
ABSTRACT A safe and rapid one‐pot synthesis of azidochlorides with cheap and readily available raw materials without any catalyst is reported. This method utilizes stable and nonexplosive TMSN 3 as an azide source, which reacts with sodium hypochlorite in the presence of acetic acid to deliver ClN 3 . The in situ generated ClN 3 then reacts with olefins to give the difunctionalized azidochlorides with exclusive regioselectivity, yielding 25 diverse products in 43%–93% yields. Their synthetic application was demonstrated by converting to a variety of 1,2,3‐triazoles with high yields (24 examples).
Fields of Study & Subjects
Click Chemistry and Applications
Synthesis and Catalytic Reactions
Chemical Synthesis and Reactions
Publication details
- Journal / source
- ChemistrySelect
- Volume
- 11
- Issue
- 5
- Publication date
- 30 January 2026
- Language
- EN