Recent Advances in the Synthesis of Lentiginosine and Its Epimers

ChemistrySelect 2026

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Authors: Tian Jin, Xiao‐Fen Peng, Lu Zhao, Hong‐Ping Wang, Chichong Lu, Bo Liu, Zong‐He Li, Liang Sun, Won‐Hun Ham
DOI: 10.1002/slct.202506854
Cited by: 0
References: 103

Abstract

ABSTRACT (+)‐Lentiginosine is an indolizidine natural product, with its non‐natural synthetic enantiomer being (−)‐lentiginosine. Both (+)‐lentiginosine and (−)‐lentiginosine exhibit diverse bioactivities, such as antitumor, anti‐HIV, and immunomodulatory effects, which have therefore attracted significant attention from synthetic chemists. This review focuses on the synthesis of lentiginosine and its epimers, covering the period from 2006 to 2025.

Fields of Study & Subjects

Advanced Synthetic Organic Chemistry Synthesis and bioactivity of alkaloids Synthesis and Biological Activity

Publication details

Journal / source
ChemistrySelect
Volume
11
Issue
6
Publication date
1 February 2026
Language
EN