Alternative Synthesis of Click Sphingosine via Olefin Cross Metathesis Followed by the Seyferth–Gilbert Reaction
Abstract
ABSTRACT An alternative path to obtain three terminally functionalized sphingosines with acetylene, aldehyde, and carboxyl functions using olefin metathesis as a key step is reported. All these analogues of natural sphingosine can be used for imaging or derivatization.
Fields of Study & Subjects
Synthetic Organic Chemistry Methods
Sphingolipid Metabolism and Signaling
Pharmacological Receptor Mechanisms and Effects
Publication details
- Journal / source
- ChemistrySelect
- Publisher
- Wiley
- Volume
- 11
- Issue
- 6
- Publication date
- 1 February 2026
- Language
- EN