Multicomponent Synthesis of Non‐Heterocycles: Synthetic and Few Catalytic Reusability Protocol

ABSTRACT The synthetic and medicinal chemists' toolboxes include multicomponent reactions (MCRs). A number of synthetic transformations have made strategic use of these reactions, as opposed to the more laborious and step‐intensive traditional approaches. An attractive instrument for the production of a library of novel chemical entities (NCEs), the MCR method offers excellent yields, atom/step economy, shortened reaction time, and is environmentally benign. It is particularly useful in the drug development process. Research into MCRs has been very fruitful, leading to several advancements in the area. Innovative synthetic methods, including as C─H activation, cycloaddition and coupling reactions have combined to pave the way for a wide variety of organic frameworks to be accessible. Here we provide a concise overview of the synthetic procedures, recyclability methods, and the mechanistic insights gained from MCRs and their recent advances over the last quindecennial (2010–till now).