An Efficient and Greener Two‐Step Synthesis of Nintedanib: A Scalable Process Development

ChemistrySelect 2026

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Authors: Sohini Chatterjee, Sabyasachi Halder, Souvik Barman, Ashok Kumar Sharma, Gautam Panda
DOI: 10.1002/slct.202507460
Cited by: 0
References: 11

Abstract

ABSTRACT We report a concise and scalable two‐step synthesis of Nintedanib, a clinically important antifibrotic agent. The route was strategically streamlined by eliminating the protection–deprotection steps required in earlier processes. Systematic optimization of reaction conditions and catalyst–ligand combinations delivered a robust transformation with improved overall yield. The methodology exhibits favorable green metrics, including enhanced atom economy, thereby representing a more sustainable alternative for large‐scale preparation and pharmaceutical process development.

Fields of Study & Subjects

Multicomponent Synthesis of Heterocycles Catalytic Cross-Coupling Reactions Microwave-Assisted Synthesis and Applications

Publication details

Journal / source
ChemistrySelect
Volume
11
Issue
1
Publication date
1 January 2026
Language
EN