Silver‐Catalyzed Intermolecular Cyclization/[4+2] Cycloaddition of 2‐(1‐Alkynyl)Cyclopropylpyridines With 1,3,5‐Triazinanes To Form Aza‐Heterocycle‐Fused Indolizines
Abstract
ABSTRACT Given the broad biological activities of indolizine scaffolds, the development of efficient synthetic routes to novel indolizine frameworks remains highly desirable. Herein, we report a silver‐catalyzed tandem cyclization/[4+2] cycloaddition of 2‐(1‐alkynyl)cyclopropylpyridines with 1,3,5‐triazinanes, which provides an efficient strategy for constructing six‐membered aza‐heterocycle‐fused indolizine derivatives. Based on preliminary mechanistic studies, a plausible reaction pathway for this annulation process is proposed.
Fields of Study & Subjects
Synthesis and Reactivity of Heterocycles
Synthesis and pharmacology of benzodiazepine derivatives
Synthesis and Properties of Aromatic Compounds
Publication details
- Journal / source
- ChemistrySelect
- Volume
- 11
- Issue
- 1
- Publication date
- 1 January 2026
- Language
- EN