Visible‐Light‐Induced 3‐ H Indole Hydrogenation for Indoline Synthesis Catalyzed by Thioxanthone‐TfOH Complex
Abstract
ABSTRACT Imine hydrogenation is a fundamental transformation in organic synthetic methodology. Although numerous methods have been developed, imine reduction protocols with inert solvent hydrogen source are still unrealized. In this work, a strategy of photocatalytic imine hydrogenation with 9‐HTXTF (thioxanthone‐TfOH complex) serving as the photocatalyst and p ‐xylene serving as the hydrogen source was thoroughly investigated. This strategy, with its reaction conditions optimized, substrate scope examined, and reaction mechanism explored, provides an efficient method for synthesizing indoline derivatives.
Fields of Study & Subjects
Radical Photochemical Reactions
Asymmetric Hydrogenation and Catalysis
Synthesis of Indole Derivatives
Publication details
- Journal / source
- ChemistrySelect
- Volume
- 11
- Issue
- 6
- Publication date
- 1 February 2026
- Language
- EN