TBAI‐Mediated, One‐Pot Efficient Synthesis of α‐Aminophosphonates From Aryl Azides and Phosphites
Abstract
ABSTRACT A facile synthesis of α‐aminophosphonates has been achieved via a three‐component reaction of aldehydes, azides, and triethylphosphite under solvent‐free conditions, using tetrabutylammonium iodide (TBAI) as a catalyst. In the presence of this benign iodine analogue, the one‐pot reaction efficiently afforded α‐aminophosphonates in good to excellent yields. Moreover, the present method offers metal‐free conditions, shorter reaction times, a broad substrate scope with good functional group tolerance, and facile scalability.
Fields of Study & Subjects
Organophosphorus compounds synthesis
Sulfur-Based Synthesis Techniques
Click Chemistry and Applications
Publication details
- Journal / source
- ChemistrySelect
- Publisher
- Wiley
- Volume
- 11
- Issue
- 28
- Publication date
- 1 July 2026
- Language
- EN