Geometrically Well‐Controlled Wireframe RNA Nanostructures With Bundled‐Helix Edges

Small 2026

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Authors: Yan Qin, Chengde Mao, Bryan Wei
DOI: 10.1002/smll.202510847
Cited by: 0
References: 40

Abstract

Wireframe RNA nanostructures with defined geometry are desirable, but bendable RNA edges can lead to structural deformation. Here, we present our design of single-stranded RNA Origami with bundled duplexes as edges. With dual duplex bundles as the wireframe edges, a specific geometry results for our RNA constructs. We construct a number of complex RNA polygons and grids with high yield and quality. Our approach can further expand the RNA design possibilities and enable downstream biomedical applications.

Fields of Study & Subjects

RNA and protein synthesis mechanisms Advanced biosensing and bioanalysis techniques DNA and Nucleic Acid Chemistry

Publication details

Journal / source
Small
Volume
22
Issue
23
Pages
e10847–e10847
Publication date
23 February 2026
Language
EN