Corneal Nerve Regeneration via MSC‐Derived EVs: Tissue Source and Culture Dimensionality Dictate miRNA Cargo and Therapeutic Efficacy (Small 6/2026)

Small 2026 Open access

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Authors: Hamed Massoumi, Eitan A. Katz, Melinda Alviar, Qiang Zhou, Mauricio Gonzalez Oyarzun, Deepshikha Tewari, Makayla Dove, Hanieh Niktinat, Tara Nguyen, Seyed Mahbod Baharnoori, Khandaker N. Anwar, Mark Maienschein‐Cline
+6 more Yuanxiang Li, Xiaowei Wang, Victor H. Guaiquil, Mark I. Rosenblatt, Ali R. Djalilian, Elmira Jalilian
DOI: 10.1002/smll.72029
Cited by: 0

Abstract

Extracellular Vesicles In article number e07451, Elmira Jalilian and co-workers investigated how tissue source and culture dimensionality dictate the cargo and efficacy of extracellular vesicles (EVs). The artwork depicts EVs (gold spheres) delivering their distinct miRNA cargo to damaged neurons, facilitating neurotrophic signalling and extracellular matrix remodelling. This study highlights that 3D culture significantly enhances EV yield and regenerative potency, establishing a framework for designing precise, cell-free therapies for ocular nerve repair.

Fields of Study & Subjects

Extracellular vesicles in disease Nerve injury and regeneration Mesenchymal stem cell research

Publication details

Journal / source
Small
Volume
22
Issue
6
Publication date
1 January 2026
Language
EN