Bimetallic Au–Ag Nanoclusters as a Photo‐Responsive Oxidase‐Like Nanozyme for Antioxidant Detection and Intracellular Redox Analysis

Small Science 2026 Open access

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Authors: Sanskruti Swain, I-Hsuan Chou, Bikash Chandra Mallick, Shu‐Chen Liu, Gin-Shin Chen, Hsing‐Ying Lin, Chen‐Han Huang
DOI: 10.1002/smsc.202500560
Cited by: 1
References: 48

Abstract

Bimetallic nanoclusters (NCs) hold promise as catalytic materials, yet their potential as enzyme mimics remains largely unexplored. Here, we report the first demonstration that gold–silver nanoclusters (AuAgNCs) function as photo‐responsive oxidase‐like nanozymes. Under visible‐light irradiation, AuAgNCs catalyze thiamine oxidation via a Type I photosensitization pathway, predominantly generating physiologically relevant peroxyl radicals (ROO•). The AuAgNCs outperform monometallic analogs, achieving enhanced catalytic efficiency with lower K m and higher v max than previously reported nanozymes. Utilizing these capabilities, we established a rapid (

Fields of Study & Subjects

Advanced Nanomaterials in Catalysis Nanocluster Synthesis and Applications Nanoplatforms for cancer theranostics

Publication details

Journal / source
Small Science
Publisher
Wiley
Volume
6
Issue
2
Pages
e202500560–e202500560
Publication date
1 February 2026
Language
EN