Alternating Electric Field‐Assisted Matrix Nano‐Coating for High Spatial Resolution MALDI Imaging (Small Methods 3/2026)

Small Methods 2026 Open access

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Authors: Hua Guo, Jinming Li, Hao Hu, Liang Qin, Lulu Chen, Qichen Hao, Chenyu Yang, Ran Wu, Jie Feng, Rui Liu, D. H. Chen, Wei Bo Li
+2 more Shuyu Hao, Xiaodong Wang
DOI: 10.1002/smtd.70408
Cited by: 0

Abstract

Inside Front Cover In article number 2500785, Li, Hao, Wang, and co-workers illustrate alternating electric field-assisted matrix nano-coating (AEFAMnC), a novel matrix deposition technique. By utilizing alternating electric-fields, it enables repetitive micro-extraction of analytes and nanoscale ultra-uniform matrix coating. This significantly boosts the in-situ enrichment of endogenous compounds on sample surfaces and the matrix-analyte co-crystallization, thereby enhancing the performance of high-resolution MALDI-MSI in spatial multi-omics, especially for single-cell studies.

Fields of Study & Subjects

Mass Spectrometry Techniques and Applications Advanced Proteomics Techniques and Applications Ion-surface interactions and analysis

Publication details

Journal / source
Small Methods
Volume
10
Issue
3
Publication date
1 February 2026
Language
EN