The Effect of Mechanical Loading on Sprouting Angiogenesis from Engineered Macro‐vessel Model (Small Methods 4/2026)

Small Methods 2026

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Authors: Lior Debbi, Oryan Karni Katovich, Asaf Silverstein, Theodor Fuchs, Christopher S. Chen, Shulamit Levenberg
DOI: 10.1002/smtd.70412
Cited by: 0

Abstract

Front Cover In article number 2500850, Levenberg and co-workers developed a novel stretchable macro-vessel model embedded in collagen, subjected to distinct mechanical loading profiles to study sprouting angiogenesis. Finite-element-analysis maps strain distributions, revealing that lateral stretch enhances sprouting and alignment, while longitudinal stretch inhibits it. The study offers a predictive, controllable platform to guide vascular architecture using external mechanical cues.

Fields of Study & Subjects

Cellular Mechanics and Interactions Tissue Engineering and Regenerative Medicine 3D Printing in Biomedical Research

Publication details

Journal / source
Small Methods
Volume
10
Issue
4
Publication date
1 February 2026
Language
EN